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Finally, in a third sensitivity analysis we repeated the cumulative duration of use and cumulative dosage analyses by categorising these variables in tertile categories, based on the distribution of use in the controls.

Pioglitazone is a selective peroxisome proliferator-activated receptor-gamma ( PPARgamma) agonist, used to treat diabetes.

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The third drug may be an oral agent from a third class of antidiabetic drugs, basal insulin (typically at bedtime), or the injectable drug exenatide.

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